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Approximately 350 workers, members of Unite Here Local 2, begin picket in front of the hotel at 2 Montgomery St. at about 4 a.m., union leaders said.

Stick points in the discussions include hotel management's application to reduce health and retirement benefits.

The strike, predictable to last until Friday morning, comes on the heels of a three-day strike by workers at the Grand Hyatt last week. Mayor Gavin Newsom has stepped in to assist with the contract talks.

The union, which is negotiate separately with hotels including the Hyatt, Hilton, Marriott, Star wood and Intercontinental, represents thousands of employees in the hospitality industry, including room cleaners, cooks, food servers, bellmen, bartenders and dishwashers.